The Bioresorption Process
The PCL microspheres bioresorb into the non-toxic degradation products of carbon dioxide and water and are excreted through normal metabolic pathways (representing total bioresorbability). The complete and controlled bioresorption of PCL has been proven via radio-labelled PCL microsphere implantation studies (3H- and C14-labelled)1-5.
The mechanism of bioresorption of the polycaprolactone (PCL) microspheres is defined by two predictable and controlled phases;
- During the initial phase, the PCL chain-length is reduced by chain scission (hydrolysis), but is not yet resorbed, keeping the microsphere intact with no volume or mass loss
- During the second phase, after the desired longevity has been obtained, total bioresorption takes place through volume and mass loss and excretion occurs through the normal metabolic pathways (citric acid cycle) as carbon dioxide and water1-5.